Title : Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.

Pub. Date : 2017 May 1

PMID : 28249908






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Treatment with GSK2334470 or the CDK2 inhibitor dinaciclib was sufficient to reverse these events and to restore the sensitivity of ribociclib-resistant cells to CDK4/6 inhibitors. dinaciclib cyclin dependent kinase 2 Homo sapiens