Title : Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.

Pub. Date : 2017 Feb 14

PMID : 28246472






1 Functional Relationships(s)
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1 Dramatically increased CCAAT-enhancer-binding protein homologous protein level, suppressed COX-2 and decreased Bcl-2/Bax ratio by melatonin or ATF-6 siRNA contributed the enhanced HepG2 cell apoptosis under tunicamycin (an ER stress inducer) stimulation. Tunicamycin activating transcription factor 6 Homo sapiens