Protein Name activating transcription factor 6
Organism Homo sapiens
Gene ID 22926
Gene Symbol


UniProt P18850 (ATF6A_HUMAN), A8K383 (A8K383_HUMAN)
Relationships Total Number of functionally related compound(s) : 219
Total Number of Articles : 285

activating transcription factor 6

Gene Summary

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

  • cyclic AMP-dependent transcription factor ATF-6 alpha
  • cAMP-dependent transcription factor ATF-6 alpha
  • ACHM7
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