Pub. Date : 2017 Apr 15
PMID : 28242322
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results demonstrated that most of the tested pyrethroids showed moderate to weak inhibitory effects against both CES1 and CES2, but deltamethrin displayed strong inhibition towards CES1. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 2 | The IC50 values of deltamethrin against CES1-mediated BMBT, DME, and DMCB hydrolysis were determined as 1.58muM, 2.39muM, and 3.3muM, respectively. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 3 | Moreover, deltamethrin was cell membrane permeable and capable of inhibition endogenous CES1 in living cells. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 4 | Further investigation revealed that deltamethrin inhibited CES1-mediated BMBT hydrolysis via competitive manner but noncompetitively inhibited DME or DMCB hydrolysis. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 5 | The inhibition behaviors of deltamethrin against CES1 were also studied by molecular docking simulation. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 6 | The results demonstrated that CES1 had at least two different ligand-binding sites, one was the DME site and another was the BMBT site which was identical to the binding site of deltamethrin. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 7 | In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT. | decamethrin | carboxylesterase 1 | Homo sapiens |
| 8 | In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT. | decamethrin | carboxylesterase 1 | Homo sapiens |