Pub. Date : 2017 Feb 28
PMID : 28241849
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Results of western blot confirm that metformin and ATO cooperated to inhibit mTORC1, activate AMP-activated protein kinase (AMPK), and upregulate ERK3. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Inactivation of p38 MAPK by SB203580 or specific short interfering RNA (siRNA) promoted the inactivation of mTORC1 in ICC cells treated with metformin and ATO. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | CONCLUSIONS: Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |