PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28241849-15	2017	Results of western blot confirm that metformin and ATO cooperated to inhibit mTORC1, activate AMP-activated protein kinase (AMPK), and upregulate ERK3.	Metformin	37-46	CREB regulated transcription coactivator 1	Mus musculus	77-83	
28241849-17	2017	Inactivation of p38 MAPK by SB203580 or specific short interfering RNA (siRNA) promoted the inactivation of mTORC1 in ICC cells treated with metformin and ATO.	Metformin	141-150	CREB regulated transcription coactivator 1	Mus musculus	108-114	
28241849-23	2017	CONCLUSIONS: Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways.	Metformin	13-22	CREB regulated transcription coactivator 1	Mus musculus	136-142