Title : GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.

Pub. Date : 2017 Jun

PMID : 28228639






1 Functional Relationships(s)
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1 GluN1-G620R/GluN2A complexes showed a mild reduction in trafficking, a ~2-fold decrease in glutamate and glycine potency, a strong decrease in sensitivity to Mg2+ block, and a significant reduction of current responses to a maximal effective concentration of agonists. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens