Title : Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.

Pub. Date : 2017 Feb 13

PMID : 28208810






1 Functional Relationships(s)
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1 Moreover, by using Shp2 phosphatase mutants, phosphor-tyrosine mimicking, and deficiency mutants, we provided evidence that the phosphatase activity of Shp2 and its tyrosine phosphorylation, are necessary for the IL-6-induced downregulation of E-cadherin and the phosphorylation of Erk1/2. Tyrosine interleukin 6 Homo sapiens