Pub. Date : 2017
PMID : 28199387
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dermatan sulfate is a player in the transglutaminase 2 interaction network. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 2 | The enhanced extracellular expression of TG2 is associated with processes such as wound healing, fibrosis or vascular remodeling that are also characterized by a high deposition of dermatan sulfate (DS) proteoglycans in the ECM. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 3 | The enhanced extracellular expression of TG2 is associated with processes such as wound healing, fibrosis or vascular remodeling that are also characterized by a high deposition of dermatan sulfate (DS) proteoglycans in the ECM. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 4 | However, it is unknown whether DS may bind to TG2 or affect its function. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 5 | Using the plasmon surface resonance method, we showed that DS chains, especially those of biglycan, are good binding partners for TG2. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 6 | The competitive effect of heparin on DS binding to TG2 suggests that both glycosaminoglycans occupy the same binding site(s) on the protein molecule. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 7 | An occurrence of the DS-TG2 interaction was confirmed by the co-immunoprecipitation of this protein with native decorin that is a DS-bearing proteoglycan rather than with the decorin core protein. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 8 | Moreover, in vivo DS is responsible for both TG2 binding and the regulation of the location of this protein in the ECM as can be suggested from an increased extraction of TG2 from the human fascia only when an enzymatic degradation of the tissue DS was conducted in the presence of the anti-collagen type I antiserum. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 9 | Moreover, in vivo DS is responsible for both TG2 binding and the regulation of the location of this protein in the ECM as can be suggested from an increased extraction of TG2 from the human fascia only when an enzymatic degradation of the tissue DS was conducted in the presence of the anti-collagen type I antiserum. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 10 | In addition, DS with a low affinity for TG2 exerted an inhibitory effect on the protein transamidating activity most probably via the control of the accessibility of a substrate. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |
| 11 | Our data show that DS can affect several aspects of TG2 biology in both physiological and pathological conditions. | Dermatan Sulfate | transglutaminase 2 | Homo sapiens |