Title : Metabolic gatekeeper function of B-lymphoid transcription factors.

Pub. Date : 2017 Feb 23

PMID : 28192788






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dominant-negative mutants of PAX5 and IKZF1, however, relieved this glucose and energy restriction. Glucose IKAROS family zinc finger 1 Homo sapiens
2 A CRISPR/Cas9-based screen of PAX5 and IKZF1 transcriptional targets identified the products of NR3C1 (encoding the glucocorticoid receptor), TXNIP (encoding a glucose-feedback sensor) and CNR2 (encoding a cannabinoid receptor) as central effectors of B-lymphoid restriction of glucose and energy supply. Glucose IKAROS family zinc finger 1 Homo sapiens
3 A CRISPR/Cas9-based screen of PAX5 and IKZF1 transcriptional targets identified the products of NR3C1 (encoding the glucocorticoid receptor), TXNIP (encoding a glucose-feedback sensor) and CNR2 (encoding a cannabinoid receptor) as central effectors of B-lymphoid restriction of glucose and energy supply. Glucose IKAROS family zinc finger 1 Homo sapiens