Pub. Date : 2017 Feb 10
PMID : 28187790
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid and TGF-beta signalling cooperate to overcome MYCN-induced retinoid resistance. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | METHODS: We applied RNA sequencing (RNA-seq) and interaction proteomics coupled with network-based systems level analysis to identify targetable vulnerabilities of MYCN-mediated retinoid resistance. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Co-targeting of the retinoic acid and TGF-beta pathways, through RA and kartogenin (KGN; a TGF-beta signalling activating small molecule) combination treatment, induced the loss of viability of MYCN-amplified retinoid-resistant neuroblastoma cells. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | By applying global omics approaches to the signalling networks regulating neuroblastoma differentiation and stemness, we have determined the pathways involved in the MYCN-mediated retinoid resistance, with TGF-beta signalling being a key regulator. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | These findings revealed a number of combination treatments likely to improve clinical response to retinoid therapy, including co-treatment with retinoids and KGN, which may prove valuable in the treatment of high-risk MYCN-amplified neuroblastoma. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 7 | These findings revealed a number of combination treatments likely to improve clinical response to retinoid therapy, including co-treatment with retinoids and KGN, which may prove valuable in the treatment of high-risk MYCN-amplified neuroblastoma. | Retinoids | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |