Title : The endoplasmic reticulum stress inducer thapsigargin enhances the toxicity of ZnO nanoparticles to macrophages and macrophage-endothelial co-culture.

Pub. Date : 2017 Mar

PMID : 28171821






3 Functional Relationships(s)
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1 In this study, the effects of ER stress inducer thapsigargin (TG) on the toxicity of ZnO NPs to THP-1 macrophages were investigated. Zinc Oxide GLI family zinc finger 2 Homo sapiens
2 In the co-culture, exposure of THP-1 macrophages in the upper chamber to ZnO NPs and TG significantly reduced the viability of human umbilical vein endothelial cells (HUVECs) in the lower chamber, but the release of tumor necrosis factor alpha (TNFalpha) was not induced. Zinc Oxide GLI family zinc finger 2 Homo sapiens
3 In summary, our data showed that stressing THP-1 macrophages with TG enhanced the cytotoxicity of ZnO NPs to macrophages and macrophage-endothelial co-cultures. Zinc Oxide GLI family zinc finger 2 Homo sapiens