Pub. Date : 2017 Mar 1
PMID : 28166401
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After 3 h of exposure to these platinum(II) agents, >50% of BCL-2 siRNA transcripts were platinated and unable to effectively suppress mRNA levels. | Platinum | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Coincorporation of BCL-2 siRNA and platinum(IV) analogues in a single micelle enabled maximal suppression of BCL-2 mRNA levels (to <10% of baseline), augmented the intracellular levels of platinum (by ~4x) and the numbers of resultant Pt-DNA adducts (by >5x), increased the cellular fractions that underwent apoptosis (by ~4x), and enhanced the in vitro antiproliferative activity of the corresponding platinum(II) agent (by 10-100x, depending on the cancer cell line). | Platinum | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Coincorporation of BCL-2 siRNA and platinum(IV) analogues in a single micelle enabled maximal suppression of BCL-2 mRNA levels (to <10% of baseline), augmented the intracellular levels of platinum (by ~4x) and the numbers of resultant Pt-DNA adducts (by >5x), increased the cellular fractions that underwent apoptosis (by ~4x), and enhanced the in vitro antiproliferative activity of the corresponding platinum(II) agent (by 10-100x, depending on the cancer cell line). | Platinum | BCL2 apoptosis regulator | Homo sapiens |
| 4 | Coincorporation of BCL-2 siRNA and platinum(IV) analogues in a single micelle enabled maximal suppression of BCL-2 mRNA levels (to <10% of baseline), augmented the intracellular levels of platinum (by ~4x) and the numbers of resultant Pt-DNA adducts (by >5x), increased the cellular fractions that underwent apoptosis (by ~4x), and enhanced the in vitro antiproliferative activity of the corresponding platinum(II) agent (by 10-100x, depending on the cancer cell line). | Platinum | BCL2 apoptosis regulator | Homo sapiens |