Pub. Date : 2017 May
PMID : 28163135
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DCA was found to inhibit its own metabolism by irreversibly inactivating glutathione transferase zeta 1 (GSTZ1-1), resulting in nonlinear kinetics and abnormally high accumulation ratio after repeated dosing. | Dichloroacetic Acid | glutathione S-transferase zeta 1 | Rattus norvegicus |
| 2 | DCA was found to inhibit its own metabolism by irreversibly inactivating glutathione transferase zeta 1 (GSTZ1-1), resulting in nonlinear kinetics and abnormally high accumulation ratio after repeated dosing. | Dichloroacetic Acid | glutathione S-transferase zeta 1 | Rattus norvegicus |
| 3 | The maximum rate constant for DCA-induced GSTZ1-1 inactivation is estimated to be 0.96/h, which is 110 times that of the rate constant for GSTZ1-1 natural degradation (0.00875/h). | Dichloroacetic Acid | glutathione S-transferase zeta 1 | Rattus norvegicus |
| 4 | The maximum rate constant for DCA-induced GSTZ1-1 inactivation is estimated to be 0.96/h, which is 110 times that of the rate constant for GSTZ1-1 natural degradation (0.00875/h). | Dichloroacetic Acid | glutathione S-transferase zeta 1 | Rattus norvegicus |