PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28163135-2 2017 DCA was found to inhibit its own metabolism by irreversibly inactivating glutathione transferase zeta 1 (GSTZ1-1), resulting in nonlinear kinetics and abnormally high accumulation ratio after repeated dosing. Dichloroacetic Acid 0-3 glutathione S-transferase zeta 1 Rattus norvegicus 73-103 28163135-2 2017 DCA was found to inhibit its own metabolism by irreversibly inactivating glutathione transferase zeta 1 (GSTZ1-1), resulting in nonlinear kinetics and abnormally high accumulation ratio after repeated dosing. Dichloroacetic Acid 0-3 glutathione S-transferase zeta 1 Rattus norvegicus 105-112 28163135-4 2017 The maximum rate constant for DCA-induced GSTZ1-1 inactivation is estimated to be 0.96/h, which is 110 times that of the rate constant for GSTZ1-1 natural degradation (0.00875/h). Dichloroacetic Acid 30-33 glutathione S-transferase zeta 1 Rattus norvegicus 42-49 28163135-4 2017 The maximum rate constant for DCA-induced GSTZ1-1 inactivation is estimated to be 0.96/h, which is 110 times that of the rate constant for GSTZ1-1 natural degradation (0.00875/h). Dichloroacetic Acid 30-33 glutathione S-transferase zeta 1 Rattus norvegicus 139-146