Title : The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia.

Pub. Date : 2016

PMID : 28149280






3 Functional Relationships(s)
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1 The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia. AZD 6244 interleukin 6 Homo sapiens
2 Moreover, Selumetinib has also been shown to inhibit the production of IL-6. AZD 6244 interleukin 6 Homo sapiens
3 Treatment with Selumetinib reduced tumor mass and reduced circulating and tumor IL-6; however MEK inhibition did not preserve muscle mass. AZD 6244 interleukin 6 Homo sapiens