Title : Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons.

Pub. Date : 2017 Jan 30

PMID : 28134307






1 Functional Relationships(s)
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1 Using a combination of biochemical assays, live imaging and electrophysiology we demonstrate that FTY720 induces a rapid increase in GLUN2A-containing neuroprotective NMDARs on the surface of dendritic spines in cultured hippocampal neurons. Fingolimod Hydrochloride glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus