Protein Name glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Organism Mus musculus
Gene ID 14811
Gene Symbol

Grin2a

UniProt P35436 (NMDE1_MOUSE)
Relationships Total Number of functionally related compound(s) : 138
Total Number of Articles : 214
Description

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

Gene Summary

Enables NMDA glutamate receptor activity and calcium channel activity. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including glutamatergic synapse; synaptic membrane; and synaptic vesicle. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • glutamate receptor ionotropic, NMDA 2A
  • N-methyl D-aspartate receptor subtype 2A
  • glutamate [NMDA] receptor subunit epsilon-1
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Properties