Pub. Date : 2017 Apr
PMID : 28129433
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Recently, we have reported that cadmium (Cd) activates c-Jun N-terminal kinase (JNK) pathway leading to neuronal cell death by inducing ROS inactivation of protein phosphatase 5 (PP5), and celastrol prevents Cd-activated JNK pathway against neuronal apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Recently, we have reported that cadmium (Cd) activates c-Jun N-terminal kinase (JNK) pathway leading to neuronal cell death by inducing ROS inactivation of protein phosphatase 5 (PP5), and celastrol prevents Cd-activated JNK pathway against neuronal apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | Therefore, we hypothesized that celastrol could hinder Cd induction of ROS-dependent PP5-JNK signaling pathway from apoptosis in neuronal cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 5 | Furthermore, we noticed that expression of wild-type PP5 or dominant negative c-Jun, or pretreatment with JNK inhibitor SP600125 reinforced celastrol"s suppression of Cd-induced NOX2 and its regulatory proteins, and consequential ROS in neuronal cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 6 | These findings indicate that celastrol ameliorates Cd-induced neuronal apoptosis via targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |