Title : Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.

Pub. Date : 2017 Mar 5

PMID : 28119076






2 Functional Relationships(s)
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1 Conversely, intrathecal injection of the JNK inhibitor SP600125 prevented SNI and ddC-induced nociceptive behavior and, its inactive dose co-administrated with amitriptyline induced an antinociceptive effect. Zalcitabine mitogen-activated protein kinase 8 Mus musculus
2 Western blotting analysis showed an upregulation of p-JNK in the lumbar spinal cord of SNI and ddC-exposed mice, that was further enhanced after amitriptyline administration. Zalcitabine mitogen-activated protein kinase 8 Mus musculus