Title : Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway.

Pub. Date : 2017 Feb 15

PMID : 28119074






5 Functional Relationships(s)
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1 Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway. celastrol NFE2 like bZIP transcription factor 2 Homo sapiens
2 In contrast, celastrol effectively suppressed reactive oxygen species generation, improved endothelial cell activity, and ameliorated Ang II-mediated HUVEC injury through activation of Nrf2, inhibition of Nox2/AT1 receptor expression, and upregulated phosphorylation of ERK1/2. celastrol NFE2 like bZIP transcription factor 2 Homo sapiens
3 After treatment with brusatol, a specific inhibitor of Nrf2, the protective effects of celastrol on Ang II-induced damage in HUVECs were remarkably alleviated. celastrol NFE2 like bZIP transcription factor 2 Homo sapiens
4 Taken together, celastrol-induced activation of Nrf2 and inhibition of NADPH oxidase activity were critical for the inhibition of Ang II-mediated endothelial dysfunction, and demonstrated the potential application of celastrol in CVD therapy. celastrol NFE2 like bZIP transcription factor 2 Homo sapiens
5 Taken together, celastrol-induced activation of Nrf2 and inhibition of NADPH oxidase activity were critical for the inhibition of Ang II-mediated endothelial dysfunction, and demonstrated the potential application of celastrol in CVD therapy. celastrol NFE2 like bZIP transcription factor 2 Homo sapiens