Title : The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy.

Pub. Date : 2017 Apr

PMID : 28107698






1 Functional Relationships(s)
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1 The combination of the IC50 doses of apigenin (15muM) and cisplatin (7.5muM) for 48h significantly enhanced cisplatin"s cytotoxic and apoptotic effects through downregulation of Bcl-2, sharpin and survivin; and upregulation of caspase-8, Apaf-1 and p53 mRNA expression. Cisplatin BCL2 apoptosis regulator Homo sapiens