Pub. Date : 2017 Jan 19
PMID : 28102849
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy. | bbr-sdt | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy. | bbr-sdt | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Taken together, these results demonstrate that BBR-SDT effectively promotes cholesterol efflux by increasing reactive oxygen species generation, and this subsequently induces autophagy via the PI3K/AKT/mTOR signaling pathway in both "normal" macrophages and lipid-loaded macrophages (foam cells). | bbr-sdt | mechanistic target of rapamycin kinase | Homo sapiens |