Pub. Date : 2016 Dec
PMID : 28101169
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, following treatment with 20 microM cisplatin, reduced expression of beta-catenin and JNK (P<0.05 and P<0.01 respectively), and increased expression of CaMKII (P<0.01), was observed in SKOV3 and SKOV3/DPP cell lines. | Cisplatin | catenin beta 1 | Homo sapiens |
| 2 | Furthermore, inhibition of beta-catenin signaling by XAV-939 effectively reversed cisplatin chemoresistance in SKOV3/DDP cells. | Cisplatin | catenin beta 1 | Homo sapiens |
| 3 | In conclusion, abnormal activation of Wnt/beta-catenin and Wnt/JNK signaling pathways in ovarian cancer cells promotes cisplatin resistance, while the Wnt/Ca2+ signaling pathway reduces cisplatin resistance. | Cisplatin | catenin beta 1 | Homo sapiens |