Title : De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Pub. Date : 2017 Jan 17

PMID : 28096507






5 Functional Relationships(s)
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1 The enzymatic activity of the Src family tyrosine kinase p56Lck (Lck) is tightly controlled by differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505 Phosphorylation of Tyr394 and the conformational opening of Lck are believed to activate the kinase, whereas Tyr505 phosphorylation is thought to generate a closed, inactive conformation of Lck. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
2 The enzymatic activity of the Src family tyrosine kinase p56Lck (Lck) is tightly controlled by differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505 Phosphorylation of Tyr394 and the conformational opening of Lck are believed to activate the kinase, whereas Tyr505 phosphorylation is thought to generate a closed, inactive conformation of Lck. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
3 The enzymatic activity of the Src family tyrosine kinase p56Lck (Lck) is tightly controlled by differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505 Phosphorylation of Tyr394 and the conformational opening of Lck are believed to activate the kinase, whereas Tyr505 phosphorylation is thought to generate a closed, inactive conformation of Lck. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
4 The enzymatic activity of the Src family tyrosine kinase p56Lck (Lck) is tightly controlled by differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505 Phosphorylation of Tyr394 and the conformational opening of Lck are believed to activate the kinase, whereas Tyr505 phosphorylation is thought to generate a closed, inactive conformation of Lck. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
5 With this approach, we separated the conformational changes of Lck from the phosphorylation state of its regulatory tyrosines. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens