Pub. Date : 2017 Feb 15
PMID : 28094183
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors. | 7-azaindole dimer | AXL receptor tyrosine kinase | Homo sapiens |
| 2 | In this context, we started to design new kinase inhibitors targeting AXL from the 7-azaindole scaffold well known to interact with the ATP binding site of the kinase. | 7-azaindole dimer | AXL receptor tyrosine kinase | Homo sapiens |
| 3 | Focused screening and chemical diversification around 7-azaindole scaffold were developed, based on modeling studies and medicinal chemistry rational, leading to the discovery of a new family of hits with potent inhibitory activity against AXL. | 7-azaindole dimer | AXL receptor tyrosine kinase | Homo sapiens |