Title : Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell.

Pub. Date : 2016

PMID : 28090191






2 Functional Relationships(s)
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1 Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells. ursolic acid catenin beta 1 Homo sapiens
2 Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, beta-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells. ursolic acid catenin beta 1 Homo sapiens