Pub. Date : 2017 Mar
PMID : 28082123
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating alpha7nAChR/PI3K/Trx-1 and suppressing ER stress. | Nicotine | thioredoxin 1 | Mus musculus |
| 2 | The expression of thioredoxin-1(Trx-1) was decreased by MPP+, which was restored by nicotine. | Nicotine | thioredoxin 1 | Mus musculus |
| 3 | Consistently, pretreatment with nicotine ameliorated the motor ability, restored the declines of Trx-1 and tyrosine hydroxylase (TH), and suppressed the expressions of Bip and CHOP induced by 1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. | Nicotine | thioredoxin 1 | Mus musculus |
| 4 | Our results suggest that nicotine plays role in resisting MPP+/MPTP neurotoxicity through activating the alpha7nAChR/PI3K/Trx-1 pathway and suppressing ER stress. | Nicotine | thioredoxin 1 | Mus musculus |