PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28082123-0	2017	Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating alpha7nAChR/PI3K/Trx-1 and suppressing ER stress.	Nicotine	0-8	thioredoxin 1	Mus musculus	87-92	
28082123-5	2017	The expression of thioredoxin-1(Trx-1) was decreased by MPP+, which was restored by nicotine.	Nicotine	84-92	thioredoxin 1	Mus musculus	32-37	
28082123-8	2017	Consistently, pretreatment with nicotine ameliorated the motor ability, restored the declines of Trx-1 and tyrosine hydroxylase (TH), and suppressed the expressions of Bip and CHOP induced by 1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice.	Nicotine	32-40	thioredoxin 1	Mus musculus	97-102	
28082123-9	2017	Our results suggest that nicotine plays role in resisting MPP+/MPTP neurotoxicity through activating the alpha7nAChR/PI3K/Trx-1 pathway and suppressing ER stress.	Nicotine	25-33	thioredoxin 1	Mus musculus	122-127