Title : Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis.

Pub. Date : 2017 Feb

PMID : 28070729






1 Functional Relationships(s)
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1 Co-treatment with CI radiation and CQ could block autophagy through the IRE1/JNK/Beclin-1 axis and enhance apoptotic cell death via the activation of C/EBP homologous protein (CHOP) by the IRE1 pathway rather than PERK in vitro and in vivo. Chloroquine beclin 1, autophagy related Mus musculus