Title : Cisplatin-induced necroptosis in TNFα dependent and independent pathways.

Pub. Date : 2017 Feb

PMID : 28065786






6 Functional Relationships(s)
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1 Cisplatin-induced necroptosis in TNFalpha dependent and independent pathways. Cisplatin tumor necrosis factor Mus musculus
2 Moreover, we demonstrate that the mitochondrial permeability transition pore opening (mPTP) opening and reactive oxygen species (ROS) generation is a critical downstream event of the formation of necrosome in cisplatin-induced necroptosis, which is TNFalpha independent. Cisplatin tumor necrosis factor Mus musculus
3 Both deletion of CypD and TNFalpha completely blocked cisplatin-induced cell death, suggesting that cisplatin could induce necroptosis through TNFalpha dependent and independent pathway. Cisplatin tumor necrosis factor Mus musculus
4 Both deletion of CypD and TNFalpha completely blocked cisplatin-induced cell death, suggesting that cisplatin could induce necroptosis through TNFalpha dependent and independent pathway. Cisplatin tumor necrosis factor Mus musculus
5 Both deletion of CypD and TNFalpha completely blocked cisplatin-induced cell death, suggesting that cisplatin could induce necroptosis through TNFalpha dependent and independent pathway. Cisplatin tumor necrosis factor Mus musculus
6 Both deletion of CypD and TNFalpha completely blocked cisplatin-induced cell death, suggesting that cisplatin could induce necroptosis through TNFalpha dependent and independent pathway. Cisplatin tumor necrosis factor Mus musculus