Title : Amelioration of apelin-13 in chronic normobaric hypoxia-induced anxiety-like behavior is associated with an inhibition of NF-κB in the hippocampus.

Pub. Date : 2017 Apr

PMID : 28065733






3 Functional Relationships(s)
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1 Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity. 1-hydroxy-11-norcadinan-5-en-4-one nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity. 1-hydroxy-11-norcadinan-5-en-4-one nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 In conclusion, the present results illustrated that inhibition of APJ and promotion of NF-kappaB activation in the microglial of hippocampus might be involved in anxiogenic effect in CNH-exposed mice, and apelin-13 ameliorates CNH-induced anxiety-like behavior might be associated with an inhibition of NF-kappaB activation. 1-hydroxy-11-norcadinan-5-en-4-one nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus