Title : Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.

Pub. Date : 2017 Mar

PMID : 28062277






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In these cells, arsenite induced increases of EZH2 and cyclin D1 and accelerated the cell cycle. arsenite cyclin D1 Homo sapiens
2 Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1. arsenite cyclin D1 Homo sapiens
3 Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1. arsenite cyclin D1 Homo sapiens
4 These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation. arsenite cyclin D1 Homo sapiens