Pub. Date : 2017 Jun
PMID : 28052987
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we tested the hypothesis that cilastatin also blocks megalin-mediated uptake of vancomycin, cisplatin, colistin, and aminoglycosides, thereby limiting the nephrotoxicity of these drugs. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 2 | Quartz crystal microbalance analysis showed that megalin also binds vancomycin and cisplatin and that cilastatin competes with megalin for binding to gentamicin, colistin, vancomycin, and cisplatin. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 3 | Quartz crystal microbalance analysis showed that megalin also binds vancomycin and cisplatin and that cilastatin competes with megalin for binding to gentamicin, colistin, vancomycin, and cisplatin. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 4 | In kidney-specific mosaic megalin knockout mice treated with colistin, vancomycin, or cisplatin, the megalin-replete proximal tubule epithelial cells exhibited signs of injury, whereas the megalin-deficient cells did not. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 5 | In kidney-specific mosaic megalin knockout mice treated with colistin, vancomycin, or cisplatin, the megalin-replete proximal tubule epithelial cells exhibited signs of injury, whereas the megalin-deficient cells did not. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 6 | In kidney-specific mosaic megalin knockout mice treated with colistin, vancomycin, or cisplatin, the megalin-replete proximal tubule epithelial cells exhibited signs of injury, whereas the megalin-deficient cells did not. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |
| 7 | In conclusion, megalin blockade with cilastatin efficiently suppresses the nephrotoxicity induced by gentamicin, colistin, vancomycin, or cisplatin. | Vancomycin | low density lipoprotein receptor-related protein 2 | Mus musculus |