| Protein Name | low density lipoprotein receptor-related protein 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14725 |
| Gene Symbol | Lrp2 |
| UniProt | A2ARV4 (LRP2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
86
Total Number of Articles : 83 |
Description |
low density lipoprotein receptor-related protein 2 |
| Gene Summary |
Predicted to enable several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including circulatory system development; protein import; and vitamin D metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Jul 2025] |
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