Title : Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.

Pub. Date : 2017 Apr 1

PMID : 28052863






4 Functional Relationships(s)
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Protein Name
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1 Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C). Poly I-C RELA proto-oncogene, NF-kB subunit Homo sapiens
2 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C RELA proto-oncogene, NF-kB subunit Homo sapiens
3 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C RELA proto-oncogene, NF-kB subunit Homo sapiens
4 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C RELA proto-oncogene, NF-kB subunit Homo sapiens