Title : Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.

Pub. Date : 2017 Apr 1

PMID : 28052863






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C). Poly I-C TIR domain containing adaptor molecule 1 Homo sapiens
2 Poly(I:C) upregulates the production of multiple inflammatory mediators through the TLR3-TRIF-NF-kappaB pathway in human AVICs. Poly I-C TIR domain containing adaptor molecule 1 Homo sapiens