CPRiL

TICAM1

TIR domain containing adaptor molecule 1

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

• TIR domain-containing adapter molecule 1
• TIR domain containing adaptor inducing interferon-beta
• TIR domain-containing adapter protein inducing IFN-beta
proline-rich, vinculin and TIR domain-containing protein B
putative NF-kappa-B-activating protein 502H
toll like receptor adaptor molecule 1
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
IIAE6
MyD88-3
PRVTIRB
TICAM-1
TRIF