Title : Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes.

Pub. Date : 2017 Jan

PMID : 28027722






3 Functional Relationships(s)
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1 Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-kappaB activation in poly(I:C)-stimulated astrocytes. celastrol nuclear factor kappa B subunit 1 Homo sapiens
2 Furthermore, celastrol significantly suppressed poly(I:C)-induced activation of the NF-kappaB signaling pathway. celastrol nuclear factor kappa B subunit 1 Homo sapiens
3 These results suggest that celastrol may exert its regulatory activity by inhibiting poly(I:C)-induced expression of pro-inflammatory mediators by suppressing activation of JNK MAPK-STAT1/NF-kappaB in astrocytes. celastrol nuclear factor kappa B subunit 1 Homo sapiens