Pub. Date : 2017 Mar
PMID : 28012672
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We herein evaluated five commonly used triazole fungicides including bitertanol, hexaconazole, penconazole, tebuconazole and uniconazole for the androgenic and anti-androgenic activity using two-hybrid recombinant human androgen receptor (AR) yeast bioassay and comparatively evaluated their effects on enzymatic activity of CYP3A4 by P450-Glo CYP3A4 bioassay. | uniconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | We herein evaluated five commonly used triazole fungicides including bitertanol, hexaconazole, penconazole, tebuconazole and uniconazole for the androgenic and anti-androgenic activity using two-hybrid recombinant human androgen receptor (AR) yeast bioassay and comparatively evaluated their effects on enzymatic activity of CYP3A4 by P450-Glo CYP3A4 bioassay. | uniconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | These fungicides significantly inhibited the activity of CYP3A4 at the environmental relevant concentrations and the potency ranks as tebuconazole > uniconazole > hexaconazole > penconazole > bitertanol with the corresponding IC50 of 0.81 muM, 0.93 muM, 1.27 muM, 2.22 muM, and 2.74 muM, respectively. | uniconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |