Title : Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms.

Pub. Date : 2017 Apr

PMID : 28003340






2 Functional Relationships(s)
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1 We further found that apicidin did not affect the phosphorylation of ERK or USF1; however, ERK inhibitor U0126 blocked the effect of apicidin on ADAM10. apicidin mitogen-activated protein kinase 1 Homo sapiens
2 Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role. apicidin mitogen-activated protein kinase 1 Homo sapiens