Title : XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.

Pub. Date : 2017 Jan 5

PMID : 28002403






1 Functional Relationships(s)
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1 Indeed, remarkably, genetic deletion of Parp1 rescued normal cerebellar ADP-ribose levels and reduced the loss of cerebellar neurons and ataxia in Xrcc1-defective mice, identifying a molecular mechanism by which endogenous single-strand breaks trigger neuropathology. Ribose poly (ADP-ribose) polymerase family, member 1 Mus musculus