Pub. Date : 1989 Jun 30
PMID : 2799763
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fractionation of VSMC-conditioned medium by heparin-affigel chromatography separated three immunologically and functionally distinct PA inhibitors (PAI), namely PAI-1, PAI-2 and protease-nexin I. | Heparin | serpin family E member 1 | Homo sapiens |
| 2 | PA inhibitor 2 (PAI-2) had little affinity for heparin, whereas PA inhibitor 1 (PAI-1) bound to heparin and was eluted from the column at NaCl concentrations of 0.1 to 0.35 M. Protease-nexin I, eluted at NaCl concentrations of 0.5 M and higher. | Heparin | serpin family E member 1 | Homo sapiens |
| 3 | PA inhibitor 2 (PAI-2) had little affinity for heparin, whereas PA inhibitor 1 (PAI-1) bound to heparin and was eluted from the column at NaCl concentrations of 0.1 to 0.35 M. Protease-nexin I, eluted at NaCl concentrations of 0.5 M and higher. | Heparin | serpin family E member 1 | Homo sapiens |
| 4 | Thus, human VSMC produce all three presently known PAI and these can be separated in single heparin affinity purification step. | Heparin | serpin family E member 1 | Homo sapiens |