Pub. Date : 2017 Jan 15
PMID : 27986626
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Propofol is a commonly used intravenous anesthetic, and could attenuate cancer cells malignant potential via inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) expression. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Propofol is a commonly used intravenous anesthetic, and could attenuate cancer cells malignant potential via inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) expression. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | In the present study, we mainly focus on the mechanism by which propofol down-regulated HIF-1alpha expression and malignant potential in pancreatic cancer cells. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Propofol inhibited cells migration, expression of VEGF and HIF-1alpha, phosphorylation of extracellular regulated protein kinases (ERK), AKT, Ca2+/calmodulin dependent protein kinases II (CaMK II), and Ca2+ concentration in a concentration-dependent manner (5, 25, 50, 100muM). | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |