Pub. Date : 2017 Apr
PMID : 27983763
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results showed that myricetin significantly ameliorated TGF-beta1- or PDGF-BB-induced HSCs activation, cell migration, and extracellular matrix production; blocked TGF-beta1-induced phosphorylation of Smad2, P38, extracellular signal-regulated kinase (ERK), and protein kinase B (Akt); and downregulated PDGF-BB stimulated phosphorylation of extracellular signal-regulated kinase and Akt in HSCs in a dose-dependent manner. | myricetin | SMAD family member 2 | Mus musculus |
| 2 | Our data demonstrated that myricetin suppressed alpha-smooth muscle actin and collagen type I deposition and blocked phosphorylation of Smad2, mitogen-activated protein kinases, and Akt in CCl4 -treated mice. | myricetin | SMAD family member 2 | Mus musculus |