Pub. Date : 2017 May
PMID : 27979751
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PARP1-mediated PPARalpha poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | This poly(ADP-ribosyl)ation of PPARalpha inhibits its recruitment to target gene promoters and its interaction with SIRT1, a key regulator of PPARalpha signaling, resulting in suppression of fatty acid oxidation upregulation induced by fatty acids. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | This poly(ADP-ribosyl)ation of PPARalpha inhibits its recruitment to target gene promoters and its interaction with SIRT1, a key regulator of PPARalpha signaling, resulting in suppression of fatty acid oxidation upregulation induced by fatty acids. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 4 | This poly(ADP-ribosyl)ation of PPARalpha inhibits its recruitment to target gene promoters and its interaction with SIRT1, a key regulator of PPARalpha signaling, resulting in suppression of fatty acid oxidation upregulation induced by fatty acids. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 5 | This poly(ADP-ribosyl)ation of PPARalpha inhibits its recruitment to target gene promoters and its interaction with SIRT1, a key regulator of PPARalpha signaling, resulting in suppression of fatty acid oxidation upregulation induced by fatty acids. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 6 | CONCLUSIONS: Our data indicate that PARP1 is activated in fatty liver, which prevents maximal activation of fatty acid oxidation by suppressing PPARalpha signaling. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |