Title : Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase.

Pub. Date : 2017 Jan 11

PMID : 27959534






1 Functional Relationships(s)
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1 Furthermore, a post-chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP, with a second (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests that nucleotide binding stimulates PPi dissociation and occurs before polymerase translocation. 2',3'-dideoxy-3'-thiacytidine-5'-monophosphate DNA polymerase beta Homo sapiens