Title : Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway.

Pub. Date : 2017 Jan

PMID : 27959383






2 Functional Relationships(s)
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1 Sorafenib effectively reversed the activation status of mTORC2 induced by metformin and enhanced the suppression of the mTORC1 and MAPK pathway by metformin in HCC cells, which may be responsible for reduced proliferation upon combined treatment. Sorafenib CREB regulated transcription coactivator 2 Mus musculus
2 The metformin and sorafenib combination led to increased impaired proliferation and tumor inhibition of HCC in vitro and in vivo compared to single agent, which was partially bridged by disrupting the mTORC1/mTORC2 feedback loop. Sorafenib CREB regulated transcription coactivator 2 Mus musculus