PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27959383-4 2017 Sorafenib effectively reversed the activation status of mTORC2 induced by metformin and enhanced the suppression of the mTORC1 and MAPK pathway by metformin in HCC cells, which may be responsible for reduced proliferation upon combined treatment. Sorafenib 0-9 CREB regulated transcription coactivator 2 Mus musculus 56-62 27959383-5 2017 The metformin and sorafenib combination led to increased impaired proliferation and tumor inhibition of HCC in vitro and in vivo compared to single agent, which was partially bridged by disrupting the mTORC1/mTORC2 feedback loop. Sorafenib 18-27 CREB regulated transcription coactivator 2 Mus musculus 208-214