Title : 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.

Pub. Date : 2017 Jan 27

PMID : 27951490






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The biological assay results demonstrate the ability of several quinazoline derivatives to inhibit both acetyl and butyrylcholinesterase (AChE and BuChE) enzymes (IC50 range = 1.6-30.5 muM), prevent beta-amyloid (Abeta) aggregation (IC50 range 270 nM-16.7 muM) and exhibit antioxidant properties (34-63.4% inhibition at 50 muM). Quinazolines acetylcholinesterase (Cartwright blood group) Homo sapiens